Chicago: American Medical Association, September 1986. The same vasoconstriction action can also result in hypertension, which is a noted side effect of pseudoephedrine. Bethesda, MD: American Society of Hospital Pharmacists; 1987. p. 1446. Pseudoephedrine is a stimulant, but it is well known for shrinking swollen nasal mucous membranes, so it is often used as a decongestant. § 802(45(A)). Effidac/24 (Hogil). 1993. After the yeast has begun fermenting the dextrose, the benzaldehyde is added to the vats, and in this environment the yeast converts the ingredients to the precursor l-phenylacetylcarbinol (L-PAC). L-PAC is then chemically converted to pseudoephedrine via reductive amination. In: PDR Physicians' desk reference for nonprescription drugs. In the United States, federal laws control the sale of pseudoephedrine-containing products. Ottawa: Canadian Pharmaceutical Association; 1993. p. 143. [32] The pair missed the World Championships that year as a result of the disqualification. The constricted blood vessels now allow less fluid to leave the blood vessels and enter the nose, throat and sinus linings, which results in decreased inflammation of nasal membranes, as well as decreased mucus production. Additionally, similar decreases in meth lab incidents were seen in surrounding states, according to the report, and meth-related deaths in Oregon have dramatically risen since 2007. 19th ed. [79] Certain pharmacies in Terre Haute, Indiana do so as well.[80]. 11th ed. In: PDR Physicians' desk reference. In 2005, the Committee on Education and the Workforce heard testimony concerning education programs and state legislation designed to curb this illegal practice. In: PDR Physicians' desk reference for nonprescription drugs. 1988. AHFS Drug information 1988. [65] 1998. St. Louis: Facts and Comparisons, Inc. [April 1993]. Eltor 120 (Marion Merrell Dow). [9], Common adverse drug reactions (ADRs) associated with pseudoephedrine therapy include central nervous system stimulation, insomnia, nervousness, excitability, dizziness and anxiety. [56][57], Pseudoephedrine, ephedrine, and any product containing these substances, e.g. These restrictions became law in April 2008. Red book 1993. [65] Though the law was mainly directed at pseudoephedrine products it also applies to all over-the-counter products containing ephedrine, pseudoephedrine, and phenylpropanolamine, their salts, optical isomers, [36] In March 2014, the IOC Disciplinary Commission decided that Bäckström would be awarded the silver medal. Balminil Decongestant Syrup (Rougier). Pseudo (Mason Vit). Ottawa: Canadian Pharmaceutical Association; 1988. p. 663. In: PDR Physicians' desk reference. Pseudoephedrine Hydrochloride Extended-Release Capsules. In: PDR Physicians' desk reference for nonprescription drugs. Blood or plasma pseudoephedrine concentrations are typically in the 50–300 µg/l range in persons taking the drug therapeutically, 500–3000 µg/l in people with substance use disorder involving pseudoephedrine, or poisoned patients and 10–70 mg/l in cases of acute fatal overdose.[39][40]. Ottawa: Canadian Pharmaceutical Association; 1993. p. 1063. 1988. 33rd ed. Ottawa: Canadian Pharmacists Association; 1998. p. 558. 9th ed. Sudafed 12 Hour 120 mg extended-release caplets (BW). [52], Medications that contain more than 10% pseudoephedrine are prohibited under the Stimulants Control Law in Japan. Mechanism of action/Effect: Pseudoephedrine acts on alpha-adrenergic receptors in the mucosa of the respiratory tract, producing vasoconstriction. [19][20][21] Many retailers in the US have created corporate policies restricting the sale of pseudoephedrine-containing products. [70] The report posits that the decline in meth lab incidents in both states may be due to other factors: "Mexican traffickers may have contributed to the decline in meth labs in Mississippi and Oregon (and surrounding states) as they were able to provide ample supply of equal or greater quality meth at competitive prices". It has also been reported that pseudoephedrine, among other sympathomimetic agents, may be associated with the occurrence of stroke. 10th ed. In: Krogh CME, editor. Montvale, NJ: Medical Economics Company; 1998. p. 712-3. McEvoy GK, editor. The bulk of pseudoephedrine is produced by commercial pharmaceutical manufacturers in India and China, where economic and industrial conditions favor the mass production of pseudoephedrine for export. In: Krogh CME, editor. Dimetapp Decongestant Pediatric Drops (Whitehall-Robins). The non-liquid dose form of regulated products may only be sold in unit dose blister packs, Regulated products must be stored behind the counter or in a locked cabinet in such a way as to restrict public access, Daily sales limit—must not exceed 3.6 grams of pseudoephedrine base without regard to the number of transactions, 30-day (not monthly) sales limit—must not exceed 7.5 grams of pseudoephedrine base if sold by mail order or "mobile retail vendor", 30-day purchase limit—must not exceed 9 grams of pseudoephedrine base. Its principal mechanism of action relies on its direct action on the adrenergic receptor system. CPS Compendium of pharmaceuticals and specialties. [35], In the 2014 Summer Olympic Gamess Team Sweden and Washington Capitals ice hockey player Nicklas Bäckström was prevented from playing in the final for usage of pseudoephedrine. 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