Although sudden cardiac death (SCD) is one of the most important modes of death in Western countries, pathologists and public health physicians have not given this problem the attention it deserves. The Association for European Cardiovascular Pathology has developed these guidelines, which represent the minimum standard that is required in the routine autopsy practice for the adequate investigation of SCD. Please enable it to take advantage of the complete set of features! doi: 10.1007/s00428-015-1833-5. 2008 Jan;452(1):11-8. doi: 10.1007/s00428-007-0505-5. doi: 10.1001/jama.289.21.2849. Increased excitability of the myocardium causing propagation of... Spontaneous ventricular fibrillation . Finally, we recommend the development of regional multidisciplinary networks of cardiologists, geneticists, and pathologists. Basso C, Calabrese F, Sbaraglia M, Del Vecchio C, Carretta G, Saieva A, Donato D, Flor L, Crisanti A, Dei Tos AP. -. The majority of sudden cardiac deaths (SCDs) are attributable to atherosclerotic coronary artery disease and are manifest in the older population, whereas cardiomyopathies predominate in the young (<35 years).1 In a proportion of SCDs, a cardiac abnormality cannot be identified despite detailed histopathologic examination and toxicology screen; such cases are classified as sudden arrhythmic death syndrome (SADS).1 The recognition of SADS is imperative, because evaluation of blood relatives of th… Int J Legal Med. Changes in rates of autopsy-detected diagnostic errors over time: a systematic review. HHS COVID-19 is an emerging, rapidly evolving situation. New methods of preventing potentially fatal arrhythmias have been developed and the accurate diagnosis of the causes of SCD is now of particular importance.  |  eCollection 2020. Virchows Arch. Epub 2007 Oct 20. That’s called an autopsy. 1982;103(1):156–159. 2020 Sep;477(3):341-347. doi: 10.1007/s00428-020-02861-1. 2011 Mar;32(1):1-16. doi: 10.1097/PAF.0b013e3181c2dc96. Feasibility of postmortem examination in the era of COVID-19 pandemic: the experience of a Northeast Italy University Hospital. Virchows Arch. Epub 2020 Mar 23. doi: 10.1007/s00428-007-0505-5. Genetic analysis of sudden cardiac death victims: a survey of current forensic autopsy practices. Cardiac arrest at rest and during sport activity: causes and prevention.  |  Virchows Arch. Short axis cross sectioning of the heart specimen from mid-ventricular to apical levels. D'Silva A, Bhuva AN, van Zalen J, Bastiaenen R, Abdel-Gadir A, Jones S, Nadarajan N, Menacho Medina KD, Ye Y, Augusto J, Treibel TA, Rosmini S, Ramlall M, Scully PR, Torlasco C, Willis J, Finocchiaro G, Papatheodorou E, Dhutia H, Cole D, Chis Ster I, Hughes AD, Sharma R, Manisty C, Lloyd G, Moon JC, Sharma S. Front Physiol. 2020 Jun;22(Suppl E):E20-E24. When someone dies and it’s not clear why, a doctor usually conducts an exam of the body. Basso C, Burke M, Fornes P, Gallagher PJ, De Gouveia RH, Sheppard M, Thiene G, Van Der Wal A; Association for European Cardiovascular Pathology. Virchows Arch. Epub 2020 Apr 7. Guidelines for autopsy investigation of sudden cardiac death. Am J Forensic Med Pathol. 2003;289(21):2849–2856. We believe that their adoption throughout Europe will improve the standards of autopsy practice, allow meaningful comparisons between different communities and regions, and permit the identification of emerging patterns of diseases causing SCD. Our recommendations apply to university medical centers, regionals hospitals, and all healthcare professionals practicing pathology and forensic medicine. Autopsy; Guidelines; Protocol; Sudden cardiac death. Autopsy – Sudden Death Some common mechanisms for functional deaths are. Cardiovascular Remodeling Experienced by Real-World, Unsupervised, Young Novice Marathon Runners. 2020 Oct 7;10(10):e040815. Oliva A, Brugada R, D'Aloja E, Boschi I, Partemi S, Brugada J, Pascali VL. -, Goldstein S. The necessity of a uniform definition of sudden coronary death: witnessed death within 1 hour of the onset of acute symptoms. Basso C, et al. USA.gov. Basso C, Rizzo S, Carturan E, Pilichou K, Thiene G. Eur Heart J Suppl. Couper K, Putt O, Field R, Poole K, Bradlow W, Clarke A, Perkins GD, Royle P, Yeung J, Taylor-Phillips S. BMJ Open. Incidence of sudden cardiac death in the young: a systematic review. Basso C, Burke M, Fornes P, Gallagher PJ, de Gouveia RH, Sheppard M, Thiene G, van der Wal A; Association for European Cardiovascular Pathology. 2016;468(1):75–81. Autopsy in adults with congenital heart disease (ACHD). Pathologists are responsible for determining the precise cause and mechanism of sudden death but there is still considerable variation in the way in which they approach this increasingly complex task. Although sudden cardiac death (SCD) is one of the most important modes of death in Western countries, pathologists and public health physicians have not given this problem the attention it deserves. Pacemaker failure as a cause of sudden death. State of the art in forensic investigation of sudden cardiac death. Virchows Arch. Am Heart J. doi: 10.1136/jclinpath-2014-202700. 2018 Feb;472(2):293. doi: 10.1007/s00428-017-2244-6. Epub 2010 Jun 11. doi: 10.1016/0002-8703(82)90552-X. doi: 10.1093/eurheartj/suaa052. Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. This is necessary because of our increased understanding of the genetics of cardiovascular diseases, the availability of new diagnostic methods, and the experience we have gained from the routine use of the original guidelines. Clipboard, Search History, and several other advanced features are temporarily unavailable. Get the latest public health information from CDC: https://www.coronavirus.gov. -, Turnbull A, Osborn M, Nicholas N. Hospital autopsy: endangered or extinct? 2011 May;125(3):359-66. doi: 10.1007/s00414-010-0474-0. -, Shojania KG, et al. Epub 2017 Oct 27. Angelini A, di Gioia C, Doran H, Fedrigo M, Henriques de Gouveia R, Ho SY, Leone O, Sheppard MN, Thiene G, Dimopoulos K, Mulder B, Padalino M, van der Wal AC; Association for European Cardiovascular Pathology (AECVP). 2020 Jun;476(6):797-820. doi: 10.1007/s00428-020-02779-8. doi: 10.1136/bmjopen-2020-040815. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error, After a transection of the aorta 3 cm above the aortic valve, inspection of the coronary ostia location in the proper sinus (LCA=left coronary artery; RCA= right coronary artery). J Clin Pathol. 2015;68(8):601–604. The authors declare that they have no conflict of interest. After a transection of the aorta 3 cm above the aortic valve, inspection…, Short axis cross sectioning of the heart specimen from mid-ventricular to apical levels.…, NLM New methods of preventing potentially fatal arrhythmias have been developed and the accurate diagnosi … -, van den Tweel JG, Wittekind C. The medical autopsy as quality assurance tool in clinical medicine: dreams and realities. 2008;452(1):11–18. This site needs JavaScript to work properly. The updated guidelines include a detailed protocol for the examination of the heart and recommendations for the selection of histological blocks and appropriate material for toxicology, microbiology, biochemistry, and molecular investigation.  |  Association for European Cardiovascular Pathology, See this image and copyright information in PMC. NIH Their role will be to facilitate the identification of index cases with a genetic basis, to screen appropriate family members, and ensure that appropriate preventive strategies are implemented. The present version is an update of our original article, published 10 years ago. Keywords: Get the latest research from NIH: https://www.nih.gov/coronavirus. Guidelines for autopsy investigation of sudden cardiac death. Epub 2020 Jun 9. JAMA. Virchows Arch. Sudden Nocturnal Cardiac Death . 2020 Mar 18;11:232. doi: 10.3389/fphys.2020.00232.

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