function twitterWidgetsLoad (){ Please let us know if you agree to functional, advertising and performance cookies. } var x = document.getElementsByTagName('script')[0]; (Michael J. David Roper. If you are interested in working with the group please contact David at david dot roper at warwick dot ac dot uk. We use cookies to give you the best online experience. See publication. Chemistry. You can update your cookie preferences at any time. offers eligible public information officers paid access to a reliable news release distribution service. Luke Walton Pollock, Naomi, Rai, Megha, Simon, Kailene S., Hesketh, Sophie J., Teo, Alvin C. K., Parmar, Mayuriben, Sridhar, Pooja, Collins, Richard, Lee, Sarah C., Stroud, Zoe N., Bakker, Saskia, Muench, Stephen P., Barton, C. Howard, Hurlbut, Gregory, Roper, David I., Smith, Corinne J., Knowles, Timothy J., Spickett, Corinne M., East, J. Malcolm, Postis, Vincent, Dafforn, Tim R. Zuegg, Johannes, Muldoon, Craig, Adamson, George, McKeveney, Declan, Thanh, Giang Le, Premraj, Rajaratnam, Becker, Bernd, Cheng, Mu, Elliott, Alysha G., Huang, Johnny X., Butler, Mark S., Bajaj, Megha, Seifert, Joachim, Singh, Latika, Galley, Nicola F., Roper, David I., Lloyd, Adrian J., Dowson, Christopher G., Cheng, Ting-Jen, Cheng, Wei-Chieh, Demon, Dieter, Meyer, Evelyne E., Meutermans, Wim, Cooper, M. A. There are a range of projects ongoing within the group and we are always looking for new people interested in joining us. Majce, Vita, Ruane, Karen M., Gobec, Stanislav, Roper, David I. Acta Crystallographica. or. See Photos. David Roper. Usha, Veeraraghavan, Dover, Lynn G., Roper, David I., Besra, Gurdyal S. Lloyd, Adrian J., Gilbey, Andrea M., Blewett, Anne M., De Pascale, Gianfranco, El Zoeiby, Ahmed, Levesque, Roger C., Catherwood, Anita C., Tomasz, Alexander, Bugg, Tim, Roper, David I., Dowson, Christopher G. Rea, Dean, Hovington, Rebecca, Rakus, John F., Gerlt, John A., Fülöp, Vilmos, Bugg, Tim, Roper, David I. Alderwick, Luke J., Dover, Lynn G., Veerapen, Natacha, Gurcha, Sudagar S., Kremer, Laurent, Roper, David I., Pathak, Ashish K., Reynolds, Robert C., Besra, Gurdyal S. De Pascale, Gianfranco, Lloyd, Adrian J., Schouten, James A., Gilbey, Andrea M., Roper, David I., Dowson, Christopher G., Bugg, Tim, Cressina, Elena, Lloyd, Adrian J., De Pascale, Gianfranco, Roper, David I., Dowson, Christopher G., Bugg, Tim. Turner, Daniel J., Portman, Ian, Dafforn, Tim, Rodger, Alison, Roper, David I., Smith, Corinne J., Turner, Matthew S. Bugg, Tim, Braddick, Darren, Dowson, Christopher G., Roper, David I. Hattersley, John G., Pérez-Velázquez, J., Chappell, M. J. x.parentNode.insertBefore(s, x); 2. Email: life dot sciences at warwick dot ac dot uk Tel: +44 (0)24 765 74251 Find your friends on Facebook. David Roper is a former MRC Career Development Award fellow at the University of York and now Professor of Biochemistry and Structural Biology at the University Warwick. New TB drug candidates developed from soil bacteria. See Photos. Galley, Nicola F., O'Reilly, Amy M., Roper, David I. Paulin, Sarah, Jamshad, Mohammed, Dafforn, Tim, Garcia-Lara, Jorge, Foster, Simon J., Galley, Nicola F., Roper, David I., Rosado, Helena, Taylor, Peter W. Lloyd, Adrian J., Potter, Nicola J., Fishwick, Colin W. G., Roper, David I., Dowson, Christopher G. Dow, Claire E., Rodger, Alison, Roper, David I., Berg, Hugo van den, Meigh, Louise, Greenhalgh, Sophie A., Rodgers, Thomas L., Cann, Martin J., Roper, David I., Dale, Nicholas. ), Warwick Antimicrobial Interdisciplinary Centre (WAMIC), Warwick Integrative Synthetic Biology (WISB) Centre, Latest Press Release: See Photos. Science. [email protected] 1: Aminoacyl-tRNA synthetases Warwick Crop Centre is located on our Wellesbourne campus. This approach not only allows novel insight to the biology underpinning these pathways but also enables biotechnological exploration and exploitation. (Michael J. Ábrányi-Balogh, Péter, Petri, László, Imre, Tímea, Szijj, Péter, Scarpino, Andrea, Hrast, Martina, Mitrovic, Ana, Fonovic, Ur?a Pecar, Németh, Krisztina, Barreteau, Hélène, Roper, David I., Horváti, Kata, Ferenczy, György G., Kos, Janko, Ila?, Janez, Gobec, Stanislav, Keseru, György M. Ábrányi-Balogh, Péter, Petri, László, Imre, Tímea, Szijj, Péter, Scarpino, Andrea, Hrast, Martina, Mitrovic, Ana, Fonovic, Ur?a Pecar, Németh, Krisztina, Barreteau, Hélène, Roper, David I., Horváti, Kata, Ferenczy, György G, Kos, Janko, Ila?, Janez, Gobec, Stanislav, Keseru, György M, Hrast, Martina, Jukic, Marko, Patin, Delphine, Tod, Julie, Dowson, Christopher G., Roper, David I., Barreteau, Hélène, Gobec, Stanislav. Patents-United Kingdom-Other inventors. MRC Career Development Fellowship, 1996-2000, University of Warwick Lecturer in Structural Biology 2001-2006, University of Warwick Associate Professor of Structural Biology 2006-2014, University of Warwick Reader in Structural Biology 2014-2017, University of Warwick BBSRC-RSE Enterprise Fellow 2015-2016, University of Warwick Professor of Structural Biology 2017-present. The focus of our group is upon the enzymes involved in bacterial cell wall biosynthesis, which continues to be a validated target for the development of new antimicrobial compounds and strategies. Tran, Anh T., Watson, Emma E., Pujari, Venugopal, Conroy, Trent, Dowman, Luke J., Giltrap, Andrew M., Pang, Angel, Wong, Weng Ruh, Linington, Roger G., Mahapatra, Sebabrata, Saunders, Jessica, Charman, Susan A., West, Nicholas P., Bugg, Tim, Tod, Julie, Dowson, Christopher G., Roper, David I., Crick, Dean C., Britton, Warwick J., Payne, Richard J. Calvez, Philippe, Breukink, Eefjan, Roper, David I., Dib, Mélanie, Contreras-Martel, Carlos, Zapun, André. David Roper. Valegård, Karin, Iqbal, Aman, Kershaw, Nadia J., Ivison, David, Généreux, Catherine, Dubus, Alain, Blikstad, Cecilia, Demetriades, Marina, Hopkinson, Richard J., Lloyd, Adrian J., Roper, David I., Schofield, Christopher J., Andersson, Inger, McDonough, Michael A. Pacheco-Gómez, Raúl, Cheng, Xi, Hicks, Matthew R., Smith, Corinne J., Roper, David I., Addinall, Stephen G., Rodger, Alison, Dafforn, Tim. Please let us know if you agree to functional, advertising and performance cookies. s.src = ('https:' == document.location.protocol ? School of Life Sciences, Gibbet Hill Campus, The University of Warwick, Coventry, CV4 7AL Batson, Sarah, Rea, Dean, Fülöp, Vilmos, Roper, David I. See Photos. We also have a synthetic facility for the provision of peptidoglycan intermediates to the scientific and pharma community see www.warwick.ac.uk/go/bacwan for details. You can update your cookie preferences at any time. In addition, the group also uses synthetic and translational biology approaches to obtain and reengineer pathway intermediates as chemical probes, substrates and inhibitors. See Photos. } else { The Gram-negative outer membrane envelops the bacterium and functions as a permeability barrier against antibiotics, detergents and environmental stresses. My research interests are in focused in several main areas Our activities coordinate with other groups on a national and international basis. Current areas of research include and bacterial cell wall (peptidoglycan) biosynthesis and antibiotic resistance signalling systems as well as targeting tRNA synthetases in bacterial pathogens. EurekAlert! EurekAlert! Lockey, Christine, Edwards, Richard J., Roper, David I., Dixon, Ann M. Catherwood, Anita C., Lloyd, Adrian J., Tod, Julie A., Chauhan, Smita, Slade, Susan E., Walkowiak, Grzegorz P., Galley, Nicola F., Punekar, Avinash S., Smart, Katie, Rea, Dean, Evans, Neil D., Chappell, Michael J., Roper, David I., Dowson, Christopher G. Cook, Jonathan P., Baverstock, Tyler, McAndrew, Martin B. L., Stansfeld, Phillip J., Roper, David I., Crow, Allister, Proceedings of the National Academy of Sciences of the United States of America. (Mr Souvik Naskar), BBSRC FTMA Investigating the potential to exploit the mechanism of by which tRNA-dependent amino acid synthetases activate cognate and non-cognate amino acids as a strategy for future antibiotic development (Ricky Cain), Accelerate CHNUK AMR discovery: Establishing and exploiting a joint China/UK platform to enable high throughput fragment based inhibitor discovery, 17 Alert bid led by Nottingham: A new multi-wavelength analytical ultracentrifuge for the study of biomeolcular interactions, 5th Midlands Molecular Microbiology Meeting, Multi-Targetting of tRNA synthetases: A paradigm shift in combating AMR, Molecular Dissection of PASTA domains from Enterococci (Researcher Mobility Grant for Christopher Thoroughgood), Centre for integrative theoretical and experimental analytical science for application to bacterial cell division and Quality by Design (CAS-IDP), Team CanUK: Novel antibacterial targets, assays, probes and opportunities in bacterial cell wall biogenesis, BBSRC Link with Astra Zeneca:Reagents and assays to exploit the final steps of peptidoglycan construction, The biochemical characterisation of pivotal enzymes involved in mycobacterial peptidoglycan biosynthesis Birmingham-Warwick PG grant, (led by UCL) BBSRC project Disruption of cytoplasmic membrane-associated functions in staphylococcus aureus by epicatechin gallate led by School of Pharmacy (with Sheffield and Birmingham), Subproject for Institution # 33323 - RCHAR3009 - A new Raman instrument for polarized spectroscopy of biomacromolecular systems, A new Raman instrument for polarized spectroscopy of biomacromolecular systems.

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